Shin kun fi dacewa da Tirzepatide ko Retatrutide?

Wannan labarin zai taimake ka ka zaɓi wanda ka fi dacewa da shi ta hanyar amsa tambayoyi masu zuwa:

1. Menene bambanci tsakanin tirzepatide da retatrutide?

2. Menene amfanin tirzepatide?

3. Menene amfanin retatrutide?

4. Kwatanta Fa'idodin Retatrutide da Tirzepatide

Menene bambanci tsakanin tirzepatide da retatrutide?

Babban bambanci tsakanin tirzepatide da retatrutide yana cikin tsarin su.Tirzepatide shine haɗuwa da abubuwa uku masu aiki - liraglutide, glucagon-kamar peptide-1 agonist (GLP-1);analog na oxyntomodulin;da kuma GLP-2 analogue.Retarutide, a gefe guda, ya ƙunshi sashi ɗaya mai aiki - exenatide, wani GLP-1 wanda ya wuce gona da iri a cikin pancreas.Ana amfani da magungunan biyu don sarrafa nau'in ciwon sukari na 2 ta hanyar haɓaka samar da insulin da rage matakan glucose na jini.Duk da haka, an kuma nuna retarutide don rage cin abinci yadda ya kamata fiye da tirzepatide kadai saboda tasirinsa a kan hormones da ke cikin yunwa da koshi.Don haka, ana iya amfani da shi azaman ɓangaren haɗaɗɗiyar hanya don sarrafa nauyi ga mutane masu ciwon sukari waɗanda ke da kiba ko kiba.

Menene amfanin tirzepatide?

①Ingantattun sarrafa glycemic da matakan A1C, wanda ke haifar da ingantacciyar lafiya gabaɗaya

Tirzepatide, glucagon-kamar peptide 1 agonist mai karɓa da GLP-1/glucose-dogara insulinotropic polypeptide (GIP) dual agonist, sabon zaɓi ne na magani don nau'in ciwon sukari na 2.An samo shi ya fi tasiri fiye da retatrutide a inganta sarrafa glycemic da matakan A1C.A cikin gwaje-gwaje na asibiti, an haɗa tirzepatide tare da raguwa mafi girma a cikin matakan A1C a makonni 12 idan aka kwatanta da retatrutide (-2.3% vs -1.8%), wanda ke haifar da mafi kyawun sakamakon kiwon lafiya ga marasa lafiya.

②Rage haɗarin abubuwan da ke faruwa na zuciya da jijiyoyin jini kamar bugun zuciya da bugun jini

Tirzepatide yana ba da fa'idodi iri-iri ga daidaikun mutane da ke cikin haɗari ga abubuwan da ke faruwa na zuciya kamar bugun zuciya da bugun jini.Wani bincike na 2019 da aka buga a cikin mujallar The Lancet ya gano cewa mutanen da ke shan tirzepatide suna da ƙarancin haɗarin manyan cututtukan cututtukan zuciya (MACE) idan aka kwatanta da waɗanda ke shan retatrutide.Wannan ya haɗa da raguwar 35% a cikin MACE idan aka kwatanta da retatrutide, wanda ya nuna babu wani bambanci mai mahimmanci a tasiri akan hadarin zuciya na zuciya.A cikin nazarin binciken, masu binciken sun lura cewa marasa lafiya da ke shan tirzepatide sun sami ƙananan ƙananan cututtuka na cututtukan zuciya, ciwon zuciya, rashin ciwon zuciya da bugun jini fiye da wadanda ke cikin rukunin retatrutide.Bugu da ƙari, mahalarta waɗanda suka ɗauki tirzepatide kuma sun ba da rahoton ingantattun matakan sarrafa sukarin jini da ƙarancin kiba idan aka kwatanta da waɗanda ke shan retatrutide.A ƙarshe, yana da mahimmanci a lura cewa mutanen da ke shan tirzepatide ba su da kariya daga MACE kawai amma har ma sun sami raguwa a matakan HbA1c (alama don lalacewar ciwon sukari na dogon lokaci) da yawan kitsen jiki idan aka kwatanta da matakan asali.Daga ƙarshe, waɗannan sakamakon suna nuna yiwuwar tirzepatide don rage abubuwan da ke faruwa na zuciya da jijiyoyin jini da ke hade da nau'in ciwon sukari na 2 da kuma samar da ƙarin fa'idodi masu alaƙa da tsarin jiki.

Ƙananan nauyin jiki idan aka kwatanta da retatrutide, wanda zai iya taimakawa wajen rage haɗarin cututtukan da ke da alaka da kiba
Tirzepatide yana da fa'idodi da yawa idan aka kwatanta da retatrutide, musamman idan ya zo ga nauyin jiki.Nazarin ya gano cewa tirzepatide zai iya haifar da raguwa mai mahimmanci a cikin nauyin jiki fiye da retatrutide a kan dogon lokaci.Ana iya danganta wannan ga ikonta na haɓaka ayyukan mai karɓar GLP-1 da haɓaka gamsuwa.Bugu da ƙari, an gano tirzepatide don rage kitsen ciki fiye da retatrutide, wanda zai iya taimakawa wajen rage haɗarin ciwon sukari, cututtukan zuciya, da sauran cututtuka masu alaka da kiba.Bugu da ƙari, an nuna tirzepatide don rage matakan sukari na jini fiye da retatrutide.Wadannan illolin da aka haɗa zasu iya inganta sakamakon kiwon lafiya gaba ɗaya da suka shafi kiba da rashin aiki na rayuwa.

③Ƙara yawan matakan makamashi saboda ingantaccen metabolism na glucose

Ɗaya daga cikin mahimman fa'idodin shan tirzepatide shine ikonsa na haɓaka matakan makamashi saboda ingantacciyar ƙwayar glucose.Wannan shi ne saboda GLP1 agonists mai karɓa kamar aikin tirzepatide ta hanyar ƙarfafa sakin insulin don mayar da martani ga matakan sukari na jini.Ta hanyar haɓaka samar da insulin da haɓaka metabolism na glucose, jiki zai iya amfani da ƙarin glucose don man fetur kuma wannan zai iya haifar da karuwar makamashi.Bugu da kari, GLP1 agonists masu karɓa kuma na iya rage sha'awar abinci, wanda ke haifar da rage sha'awar abinci da ingantaccen sarrafa nauyi.

Menene amfanin retatrutide?

Retatrutidemagani ne na allura da aka daɗe ana amfani da shi don magance nau'in ciwon sukari na 2.Hukumar Abinci da Magunguna ta Amurka (FDA) ta amince da ita don wannan dalili.Amfanin retatrutide yana da yawa, yana mai da shi zaɓi mai ban sha'awa tsakanin sauran magungunan ciwon sukari.

Don masu farawa, retatrutide yana aiki da sauri da zarar an yi masa allura kuma ana iya jin tasirin sa a cikin sa'o'i 24 na gudanarwa.Wannan ya sa ya fi sauri yin aiki fiye da sauran alluran da aka dade ana yin su kamar tirzepatide, wanda zai iya ɗaukar har zuwa makonni da yawa kafin a ga wani tasiri mai tasiri a matakan sukari na jini.
Bugu da ƙari, nazarin ya nuna cewa retatrutide yana da tasiri a rage matakan A1C a cikin mutanen da ke da nau'in ciwon sukari na 2 lokacin da aka ɗauka tare da abinci da canje-canje na motsa jiki.Gwajin gwaji na asibiti kuma sun nuna cewa retatrutide yana taimakawa rage matakan glucose mai azumi da kuma sarrafa glycemic gabaɗaya a cikin masu amfani idan aka kwatanta da placebo.A wasu lokuta, mutanen da ba su sami fa'ida daga magungunan ciwon sukari na baka sun sami sakamako mai nasara tare da retatrutide far.

A ƙarshe, ɗayan manyan fa'idodin retatrutide shine tsarin gudanarwa mai sauƙi;yana buƙatar allura ɗaya kawai a kowane mako maimakon yawan alluran yau da kullun kamar sauran jiyya na ciwon sukari.Wannan zai iya sa kula da ciwon sukari ya fi sauƙi kuma yana taimakawa wajen inganta tsarin kulawa da haƙuri a kan lokaci.

Kwatanta Fa'idodin Retatrutide da Tirzepatide

Lokacin da yazo ga inganci, An nuna retatrutide don rage matakan HbA1c da 1.9-2.4%, idan aka kwatanta da Tirzepatide wanda ke rage matakan HbA1c da 1.5-2%.Dukansu magunguna kuma suna da illa iri ɗaya, kamar tashin zuciya da ciwon kai.Duk da haka, wasu mutane na iya gano cewa suna fuskantar ƙarancin illa tare da Retatrutide fiye da na Tirzepatide saboda ƙananan buƙatun sa.

Dangane da aminci, Retarutide gabaɗaya ana jurewa da kyau idan aka yi amfani da shi a allurai da aka ba da shawarar kuma baya ƙara haɗarin hypoglycemia ko haifar da nauyi kamar sauran jiyya na ciwon sukari.A gefe guda, Tirzepatide yana ɗaukar haɗari mafi girma na halayen wurin allura saboda girman girmansa.Bugu da ƙari, idan an sha da yawa fiye da allurai zai iya haifar da hypoglycemia mai tsanani da karuwar nauyi.

A taƙaice, duka retarutide da tirzepatide zaɓuɓɓuka ne masu tasiri don sarrafa nau'in ciwon sukari na 2 amma ɗayan yana iya zama mafi dacewa ga wasu marasa lafiya dangane da buƙatun su.Retarutide yana ba da inganci mai kyau tare da ƙarancin sakamako masu illa yayin da yake kasancewa mafi aminci a allurai da aka ba da shawarar;duk da haka, Tirzepatide na iya bayar da raguwa mafi girma a cikin matakan HbA1c amma kuma yana iya ɗaukar haɗari mafi girma na mummunar illa idan ba a yi amfani da shi da kyau ba.Daga ƙarshe, yana da mahimmanci ku tuntuɓi likitan ku don yanke shawarar wane zaɓin magani ya fi dacewa da ku dangane da takamaiman yanayin ku da burin lafiyar ku.

Fara tirzepatide da maganin semaglutide a LianFu