Menene S-4 (Andrarine)

S-4, kasuwa kamarandarine, wani abu ne na baka, mai zaɓin mai karɓar mai karɓar mai karɓar mai karɓa (SARM) mara amfani.Andarine wani bangare ne na agonist na mai karɓar androgen.

S-4 kamar sauran SARMS an haɓaka su a farkon 2000s, a cikin ƙoƙari na shawo kan iyakokin magunguna da magunguna na steroidal androgen agonists (watau testosterone da DHT), waɗanda suka san ƙungiyoyi tare da hanta da cututtukan zuciya.

An yi amfani da Compound S-4 a nazarin dabbobi amma an yi watsi da shi kafin kowane gwaji na asibiti na mutum na Phase I, saboda nakasar gani.Wadannan tasirin suna faruwa yayin da kwayoyin S-4 ke ɗaure ga masu karɓa a cikin ido;da mafi m dauri, da karin rashin jin daɗi da aka samu.An gano rikice-rikice na gani sun zama ruwan dare gama gari, saboda aikin injina na musamman, don maganin da aka yi watsi da gwajin.

Yaya YayiS4Aikin Andarine

Ɗaya daga cikin hanyoyin da aka ba da shawara naS4, shine gaba daya ya toshe daurin DHT.Dihydrotestosterone (DHT, 5a-dihydrotestosterone, 5a-DHT, androstanolone ko stanolone) wani hormone ne na jima'i na androgen.Dangane da testosterone, DHT yana da ƙarfi sosai a matsayin agonist na mai karɓar androgen.

S-4 yana da babban mai karɓar mai karɓar isrogen (AR) mai ɗauri.Nazarin ya nuna cewa S-4 ba shi da ƙarfi kuma yana da tasiri fiye da testosterone propionate (TP) a cikin ayyukan androgenic, amma aikin su na anabolic ya kasance kama da ko mafi girma fiye da na TP.

S-4 shine cikakken agonist mai karɓar mai karɓa na androgen a cikin ƙwayar tsoka, da kuma agonist mai ban sha'awa a cikin prostate.Don haka, S-4 yana ƙarfafa haɓakar tsoka da ƙarfi, amma ya kasa kula da girman prostate.Testosterone yana ƙarfafa tsoka da haɓakar prostate zuwa daidai gwargwado.S-4 yana haifar da gagarumin luteinizing hormone (LH) ko follicle stimulating hormone suppression.

S-4 (andarine) Amfani

Kodayake an gudanar da binciken bincike da yawa, ƙarin bincike yana gudana kuma a farkon matakan ci gaba.Haɓaka SARMS don amfani da asibiti da magani azaman madadin androgen, yana da alƙawarin dangane da ainihin bayanan.

Ba kamar anabolic steroids ba, wanda ke ɗaure ga masu karɓa na androgen a cikin kyallen takarda da yawa a duk faɗin jiki, kowane SARM na mutum yana ɗaure masu karɓa na androgen a cikin wasu kyallen takarda, amma ba a cikin wasu ba.Duk da haka, har yanzu suna nuna tasirin androgenic da anabolic.

SARMS ba kwayoyin cutar anabolic ba;a maimakon haka, su ne roba ligands cewa daure zuwa androgen receptors.Dangane da tsarin kwayoyin su, suna aiki a matsayin agonists, agonists, da antagonists.Ta haka ne a cikin zaɓin zaɓi, SARMS ke daidaitawa ko daidaita masu daidaitawa da abubuwan rubutu ko siginar sunadaran cascade don haɓaka ayyukan anabolic.

Nazarin ya nuna S-4 shine cikakken agonist mai karɓar mai karɓa na androgen a cikin ƙwayar tsoka, da kuma agonist mai ban sha'awa a cikin prostate, yana mai da shi dan takarar da ya dace a matsayin madadin steroidal androgen agonists agonists (watau testosterone da DHT), saboda sakamakon illa mai haɗari. akan hanta, zuciya, da haihuwa.

Ya kamata a lura, cewa ko da yake SARMS kamar S4 yana ƙara yawan aikin androgen, ba dan takarar da ya dace ba don maganin maye gurbin hormone, tun da ba ya daɗaɗa cikin Estrogen.